The Infinite Ways Niacinamide Benefits Your Skin. Niacinamide is making an appearance in eye creams these days, and for good reason. "Niacinamide is helpful for the eyes for a combination of safety and efficacy," says Keaney. "It helps with dark circles and wrinkles, two of the major complaints of the skin around the eyes." Because there's a low risk of irritation or inflammation from using it, you can apply it to the delicate, thin skin around the eyes without worry.