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Here's How To Make Sure You're Picking The Right Hyaluronic Acid Serum. A sign of high-quality hyaluronic acid serum is a well-balanced concentration, with the percentage of hyaluronic acid in the serum sitting at just over 2% (via Ghost Democracy). Those with lower concentrations tend not to be as hydrating, while those with concentrations that are too high can absorb water away from your skin and actually dry it out.